Haplotype Analysis in Population-based Association Studies
نویسندگان
چکیده
منابع مشابه
Haplotype-based association analysis in cohort studies of unrelated individuals.
Exploring the associations between haplotypes and disease phenotypes is an important step toward the discovery of genes that influence complex human diseases. When unrelated subjects are sampled, haplotypes are often ambiguous because of the unknown gametic phase of the measured sites along a chromosome. We consider cohort studies of unrelated subjects which collect data on potentially censored...
متن کاملWHAP: haplotype-based association analysis
UNLABELLED We describe a software tool to perform haplotype-based association analysis, for quantitative and qualitative traits, in population and family samples, using single nucleotide polymorphism or multiallelic marker data. A range of tests is offered: omnibus and haplotype-specific tests; prospective and retrospective likelihoods; covariates and moderators; sliding window analyses; permut...
متن کاملEstimating haplotype relative risks on human survival in population-based association studies.
Association-based linkage disequilibrium (LD) mapping is an increasingly important tool for localizing genes that show potential influence on human aging and longevity. As haplotypes contain more LD information than single markers, a haplotype-based LD approach can have increased power in detecting associations as well as increased robustness in statistical testing. In this paper, we develop a ...
متن کاملLikelihood-Based Inference on Haplotype Effects in Genetic Association Studies
A haplotype is a specific sequence of nucleotides on a single chromosome. The population associations between haplotypes and disease phenotypes provide critical information about the genetic basis of complex human diseases. Standard genotyping techniques cannot distinguish the two homologous chromosomes of an individual so that only the unphased genotype (i.e., the combination of the two homolo...
متن کاملModeling Haplotype-Haplotype Interactions in Case-Control Genetic Association Studies
Haplotype analysis has been increasingly used to study the genetic basis of human diseases, but models for characterizing genetic interactions between haplotypes from different chromosomal regions have not been well developed in the current literature. In this article, we describe a statistical model for testing haplotype-haplotype interactions for human diseases with a case-control genetic ass...
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ژورنال
عنوان ژورنال: The Stata Journal: Promoting communications on statistics and Stata
سال: 2001
ISSN: 1536-867X,1536-8734
DOI: 10.1177/1536867x0100100104